StockDriftsStockDriftsTop 50 Opaleye Management INC Holdings
| Stock | Company | % Port. | Shares | Value | Activity | Ownership | Avg. Cost | Date |
|---|---|---|---|---|---|---|---|---|
| LQDA | LIQUIDIA CORPORATION | 17.67% | 2.45M | $195.1M | -3.83%(-97.50K) | $12.49(+522.31%) | 2026-06-30 | |
| ETON | ETON PHARMACEUTICALS INC | 9.38% | 2.86M | $103.5M | +0.00%(+0) | $5.78(+918.63%) | 2026-06-30 | |
| HROW | HARROW INC | 9.23% | 2.40M | $101.9M | -15.26%(-432.23K) | $6.49(+516.70%) | 2026-06-30 | |
| IRON | DISC MEDICINE INC | 5.66% | 855.0K | $62.5M | +103.09%(+434.00K) | $65.42(+20.51%) | 2026-06-30 | |
| URGN | UROGEN PHARMA LTD | 4.8% | 1.44M | $53.0M | +0.70%(+10.00K) | $19.31(+150.56%) | 2026-06-30 | |
| APGE | APOGEE THERAPEUTICS INC | 4.69% | 390.0K | $51.8M | +0.00%(+0) | $42.78(+214.53%) | 2026-06-30 | |
| MGTX | MEIRAGTX HLDGS PLC | 4.34% | 3.55M | $48.0M | +67.20%(+1.43M) | $9.28(+45.63%) | 2026-06-30 | |
| SLGL | SOL-GEL TECHNOLOGIES LTD | 3.36% | 500.0K | $37.1M | +0.00%(+0) | $30.85(+170.74%) | 2026-06-30 | |
| RZLT | REZOLUTE INC | 2.97% | 6.30M | $32.8M | +0.00%(+0) | $5.63(-18.22%) | 2026-06-30 | |
| TGTX | TG THERAPEUTICS INC | 2.66% | 535.0K | $29.4M | +0.00%(+0) | $16.03(+203.98%) | 2026-06-30 |
| Performance Metric | 3-Year Annualized | 3-Year Cumulative | 5-Year Annualized | 5-Year Cumulative |
|---|---|---|---|---|
| Top 20 Holdings Weighted | +40.44% | +177.01% | +9.27% | +55.79% |
| Top 20 Holdings Unweighted | +41.06% | +180.67% | +8.80% | +52.49% |
Opaleye Management INC reports $1.10B in US-listed equity holdings across 58 positions in its most recent 13F filing. Its largest disclosed positions are LQDA (17.7%), ETON (9.4%) and HROW (9.2%). The top 20 holdings account for 82.41% of reported assets. Its disclosed equity book has returned +177.01% on a three-year cumulative basis. Figures reflect the Q2 2026 filing.
Portfolio changes
Every reported change this quarter, grouped by direction. The signal is in the rotation, not any single trade.
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Holdings on this page are parsed from Opaleye Management INC’s Form 13F filings with the U.S. Securities and Exchange Commission (CIK 1595855). View Opaleye Management INC’s 13F filings on SEC