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Rock Springs Capital Management 13F Portfolio

Portfolio Manager
Rock Springs Capital Management LP
Performance
+25.42% (2026 Q2)
AUM (13F)
$2.05B
# of Holdings
104
Performance Rank
Allocation (Top 20)
58.65%
Latest filing
Q2 2026

Rock Springs Capital Management LP Holdings Map

Top 50 Rock Springs Capital Management LP Holdings

Top 10 holdings

StockCompany% Port.SharesValueActivityOwnershipAvg. CostDate
RVMD
REVOLUTION MEDICINES INC
10.1%1.11M$207.0M
-8.62%(-104.25K)
2025-Q2: 1.33M shares2025-Q3: 1.34M shares2025-Q4: 1.34M shares2026-Q1: 1.21M shares2026-Q2: 1.11M shares
$29.89(+575.87%)
2026-06-30
TVTX
TRAVERE THERAPEUTICS INC
6.04%2.18M$123.8M
+47.44%(+701.12K)
2025-Q2: 1.91M shares2025-Q3: 2.16M shares2025-Q4: 2.21M shares2026-Q1: 1.48M shares2026-Q2: 2.18M shares
$23.70(+159.22%)
2026-06-30
LLY
ELI LILLY & CO
5.78%98.7K$118.4M
+0.00%(+0)
2025-Q2: 116.5K shares2025-Q3: 105.4K shares2025-Q4: 105.4K shares2026-Q1: 98.7K shares2026-Q2: 98.7K shares
$679.21(+78.00%)
2026-06-30
MDGL
MADRIGAL PHARMACEUTICALS INC
4.59%175.0K$94.0M
+2.34%(+4.00K)
2025-Q2: 140.3K shares2025-Q3: 137.7K shares2025-Q4: 139.6K shares2026-Q1: 171.0K shares2026-Q2: 175.0K shares
$222.16(+128.38%)
2026-06-30
MIRM
MIRUM PHARMACEUTICALS INC
4.56%798.1K$93.4M
-1.62%(-13.15K)
2025-Q2: 818.2K shares2025-Q3: 761.1K shares2025-Q4: 762.3K shares2026-Q1: 811.3K shares2026-Q2: 798.1K shares
$19.44(+407.96%)
2026-06-30
RYTM
RHYTHM PHARMACEUTICALS INC
3.75%692.6K$76.9M
+0.41%(+2.85K)
2025-Q2: 861.2K shares2025-Q3: 717.1K shares2025-Q4: 695.0K shares2026-Q1: 689.7K shares2026-Q2: 692.6K shares
$18.43(+532.44%)
2026-06-30
KYMR
KYMERA THERAPEUTICS INC
2.54%453.2K$52.0M
-8.80%(-43.72K)
2025-Q2: 450.4K shares2025-Q3: 450.4K shares2025-Q4: 496.9K shares2026-Q1: 496.9K shares2026-Q2: 453.2K shares
$39.83(+182.44%)
2026-06-30
ARGX
ARGENX SE
2.39%52.8K$48.9M
-46.45%(-45.75K)
2025-Q2: 175.8K shares2025-Q3: 142.8K shares2025-Q4: 103.3K shares2026-Q1: 98.5K shares2026-Q2: 52.8K shares
$150.83(+468.15%)
2026-06-30
XENE
XENON PHARMACEUTICALS INC
2.01%683.9K$41.3M
-10.37%(-79.11K)
2025-Q2: 931.7K shares2025-Q3: 851.7K shares2025-Q4: 787.8K shares2026-Q1: 763.0K shares2026-Q2: 683.9K shares
$24.48(+164.42%)
2026-06-30
SRRK
SCHOLAR ROCK HLDG CORP
1.92%715.5K$39.3M
-3.29%(-24.36K)
2025-Q2: 794.1K shares2025-Q3: 794.1K shares2025-Q4: 733.5K shares2026-Q1: 739.8K shares2026-Q2: 715.5K shares
$26.82(+101.49%)
2026-06-30

About Rock Springs Capital Management LPโ€™s portfolio

Rock Springs Capital Management LP reports $2.05B in US-listed equity holdings across 104 positions in its most recent 13F filing. Its largest disclosed positions are RVMD (10.1%), TVTX (6.0%) and LLY (5.8%). The top 20 holdings account for 58.65% of reported assets. Its disclosed equity book has returned +45.39% on a three-year cumulative basis. Figures reflect the Q2 2026 filing.

Portfolio concentration

Portfolio concentration
RVMD โ€” 12.2% ($206.98M)TVTX โ€” 7.3% ($123.79M)LLY โ€” 7.0% ($118.38M)MDGL โ€” 5.5% ($93.97M)MIRM โ€” 5.5% ($93.44M)RYTM โ€” 4.5% ($76.90M)KYMR โ€” 3.1% ($51.96M)ARGX โ€” 2.9% ($48.94M)XENE โ€” 2.4% ($41.28M)SRRK โ€” 2.3% ($39.35M)Other โ€” 47.4% ($807.52M)
53%in top 10
  • RVMD12.2%
  • TVTX7.3%
  • LLY7.0%
  • MDGL5.5%
  • MIRM5.5%
  • RYTM4.5%
  • KYMR3.1%
  • ARGX2.9%
  • XENE2.4%
  • SRRK2.3%
  • Other47.4%

Portfolio changes

What the fund actually did

Every reported change this quarter, grouped by direction. The signal is in the rotation, not any single trade.

Added to
24
TVTXTRAVERE THERAPEUTICS INC+47.4%
CYTKCYTOKINETICS INC+314.4%
ERASERASCA INC+27.1%
INSMINSMED INC+15.2%
+20 more
Trimmed
22
ARGXARGENX SE-46.4%
RVMDREVOLUTION MEDICINES INC-8.6%
ELVNENLIVEN THERAPEUTICS INC-43.8%
AGIOAGIOS PHARMACEUTICALS INC-33.4%
+18 more

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Source filings

Holdings on this page are parsed from Rock Springs Capital Management LPโ€™s Form 13F filings with the U.S. Securities and Exchange Commission (CIK 1595725). View Rock Springs Capital Management LPโ€™s 13F filings on SEC

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