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Baker Bros Advisors 13F Portfolio

Portfolio Manager
Baker Bros Advisors LP
Performance
+11.57% (2026 Q2)
AUM (13F)
$19.96B
# of Holdings
84
Performance Rank
Allocation (Top 20)
88.02%
Latest filing
Q2 2026

Baker Bros Advisors LP Holdings Map

Top 50 Baker Bros Advisors LP Holdings

Top 10 holdings

StockCompany% Port.SharesValueActivityOwnershipAvg. CostDate
INCY
Incyte Corporation
17.48%30.76M$3.49B
+0.06%(+17.92K)
2025-Q2: 30.74M shares2025-Q3: 30.74M shares2025-Q4: 30.74M shares2026-Q1: 30.74M shares2026-Q2: 30.76M shares
$12.21(+884.16%)
2026-06-30
ONC
BeOne Medicines Ltd.
12.57%8.80M$2.51B
+0.03%(+2.51K)
2025-Q2: 8.80M shares2025-Q3: 8.80M shares2025-Q4: 8.80M shares2026-Q1: 8.80M shares2026-Q2: 8.80M shares
$71.30(+387.34%)
2026-06-30
RVMD
Revolution Medicines, Inc.
10.74%11.44M$2.14B
+19.76%(+1.89M)
2025-Q2: 9.36M shares2025-Q3: 9.46M shares2025-Q4: 9.46M shares2026-Q1: 9.56M shares2026-Q2: 11.44M shares
$48.50(+342.60%)
2026-06-30
MDGL
Madrigal Pharmaceuticals, Inc.
5.77%2.14M$1.15B
+0.07%(+1.43K)
2025-Q2: 1.98M shares2025-Q3: 2.14M shares2025-Q4: 2.14M shares2026-Q1: 2.14M shares2026-Q2: 2.14M shares
$180.43(+181.30%)
2026-06-30
ACAD
ACADIA Pharmaceuticals Inc.
5.44%42.91M$1.09B
+0.04%(+16.21K)
2025-Q2: 42.90M shares2025-Q3: 42.90M shares2025-Q4: 42.90M shares2026-Q1: 42.90M shares2026-Q2: 42.91M shares
$16.40(+72.23%)
2026-06-30
KYMR
Kymera Therapeutics, Inc.
4.97%8.66M$992.7M
+0.00%(+0)
2025-Q2: 6.65M shares2025-Q3: 6.65M shares2025-Q4: 8.66M shares2026-Q1: 8.66M shares2026-Q2: 8.66M shares
$41.46(+183.14%)
2026-06-30
INSM
Insmed Incorporated
4.7%8.80M$937.8M
+18.53%(+1.38M)
2025-Q2: 7.71M shares2025-Q3: 6.70M shares2025-Q4: 6.59M shares2026-Q1: 7.42M shares2026-Q2: 8.80M shares
$71.80(+72.34%)
2026-06-30
CELC
Celcuity Inc.
4.15%7.92M$828.2M
+0.00%(+0)
2025-Q2: 5.45M shares2025-Q3: 7.92M shares2025-Q4: 7.92M shares2026-Q1: 7.92M shares2026-Q2: 7.92M shares
$28.85(+218.84%)
2026-06-30
KOD
Kodiak Sciences Inc.
3.89%19.92M$776.1M
+0.00%(+0)
2025-Q2: 17.31M shares2025-Q3: 17.31M shares2025-Q4: 19.92M shares2026-Q1: 19.92M shares2026-Q2: 19.92M shares
$29.31(+41.06%)
2026-06-30
RYTM
Rhythm Pharmaceuticals, Inc.
3.12%5.60M$622.3M
+0.00%(+0)
2025-Q2: 5.60M shares2025-Q3: 5.60M shares2025-Q4: 5.60M shares2026-Q1: 5.60M shares2026-Q2: 5.60M shares
$22.87(+404.98%)
2026-06-30

About Baker Bros Advisors LPโ€™s portfolio

Baker Bros Advisors LP reports $19.96B in US-listed equity holdings across 84 positions in its most recent 13F filing. Its largest disclosed positions are INCY (17.5%), ONC (12.6%) and RVMD (10.7%). The top 20 holdings account for 88.02% of reported assets. Its disclosed equity book has returned +91.07% on a three-year cumulative basis. Figures reflect the Q2 2026 filing.

Portfolio concentration

Portfolio concentration
INCY โ€” 17.9% ($3.49B)ONC โ€” 12.8% ($2.51B)RVMD โ€” 11.0% ($2.14B)MDGL โ€” 5.9% ($1.15B)ACAD โ€” 5.6% ($1.09B)KYMR โ€” 5.1% ($992.73M)INSM โ€” 4.8% ($937.84M)CELC โ€” 4.2% ($828.15M)KOD โ€” 4.0% ($776.05M)RYTM โ€” 3.2% ($622.27M)Other โ€” 25.6% ($5.00B)
74%in top 10
  • INCY17.9%
  • ONC12.8%
  • RVMD11.0%
  • MDGL5.9%
  • ACAD5.6%
  • KYMR5.1%
  • INSM4.8%
  • CELC4.2%
  • KOD4.0%
  • RYTM3.2%
  • Other25.6%

Portfolio changes

What the fund actually did

Every reported change this quarter, grouped by direction. The signal is in the rotation, not any single trade.

New buys
1
SNSEFaeth Therapeutics, Inc.0.2%
Added to
15
RVMDRevolution Medicines, Inc.+19.8%
INSMInsmed Incorporated+18.5%
IDYAIDEAYA Biosciences, Inc.+26.9%
RLAYRelay Therapeutics, Inc.+143.7%
+11 more
Trimmed
6
EWTXEdgewise Therapeutics, Inc.-43.7%
SMMTSummit Therapeutics Inc.-9.9%
IMTXImmatics N.V.-12.9%
JBIOJade Biosciences, Inc.-25.0%
+2 more

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Source filings

Holdings on this page are parsed from Baker Bros Advisors LPโ€™s Form 13F filings with the U.S. Securities and Exchange Commission (CIK 1263508). View Baker Bros Advisors LPโ€™s 13F filings on SEC

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