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Commodore Capital 13F Portfolio

Portfolio Manager
Commodore Capital LP
Performance
+34.52% (2026 Q2)
AUM (13F)
$1.68B
# of Holdings
33
Performance Rank
Allocation (Top 20)
91.87%
Latest filing
Q2 2026

Commodore Capital LP Holdings Map

Top 32 Commodore Capital LP Holdings

Top 10 holdings

StockCompany% Port.SharesValueActivityOwnershipAvg. CostDate
RLAY
RELAY THERAPEUTICS INC
13.37%12.00M$224.5M
-29.41%(-5.00M)
2025-Q2: 13.35M shares2025-Q3: 17.00M shares2025-Q4: 17.00M shares2026-Q1: 17.00M shares2026-Q2: 12.00M shares
$3.36(+491.36%)
2026-06-30
ELVN
ENLIVEN THERAPEUTICS INC
9.9%3.27M$166.2M
+0.00%(+0)
2025-Q2: 4.69M shares2025-Q3: 4.69M shares2025-Q4: 4.69M shares2026-Q1: 3.27M shares2026-Q2: 3.27M shares
$18.84(+212.19%)
2026-06-30
ALKS
ALKERMES PLC
9.36%3.00M$157.2M
-28.57%(-1.20M)
2025-Q2: 2.45M shares2025-Q3: 3.10M shares2025-Q4: 3.55M shares2026-Q1: 4.20M shares2026-Q2: 3.00M shares
$28.21(+73.89%)
2026-06-30
COGT
COGENT BIOSCIENCES INC
7.03%3.05M$118.0M
+5.61%(+161.99K)
2025-Q2: 2.31M shares2025-Q3: 7.25M shares2025-Q4: 2.20M shares2026-Q1: 2.89M shares2026-Q2: 3.05M shares
$17.49(+116.83%)
2026-06-30
AMLX
AMYLYX PHARMACEUTICALS INC
6.04%5.65M$101.5M
+0.00%(+0)
2025-Q2: 0 shares2025-Q3: 4.08M shares2025-Q4: 5.65M shares2026-Q1: 5.65M shares2026-Q2: 5.65M shares
$10.79(+100.46%)
2026-06-30
DFTX
DEFINIUM THERAPEUTICS INC
5.6%2.00M$94.1M
+0.00%(+0)
2025-Q2: 0 shares2025-Q3: 0 shares2025-Q4: 0 shares2026-Q1: 2.00M shares2026-Q2: 2.00M shares
$16.14(+164.04%)
2026-06-30
SYRE
SPYRE THERAPEUTICS INC
4.48%846.8K$75.2M
-55.72%(-1.07M)
2025-Q2: 1.99M shares2025-Q3: 1.99M shares2025-Q4: 2.39M shares2026-Q1: 1.91M shares2026-Q2: 846.8K shares
$18.44(+462.10%)
2026-06-30
ANRO
ALTO NEUROSCIENCE INC
4.28%2.72M$71.9M
+0.00%(+0)
2025-Q2: 0 shares2025-Q3: 0 shares2025-Q4: 1.82M shares2026-Q1: 2.72M shares2026-Q2: 2.72M shares
$13.96(+130.22%)
2026-06-30
TNGX
TANGO THERAPEUTICS INC
4.19%2.25M$70.3Mnew2025-Q2: 1.50M shares2025-Q3: 1.50M shares2025-Q4: 0 shares2026-Q1: 0 shares2026-Q2: 2.25M shares
$10.61(+141.32%)
2026-06-30
EYPT
EYEPOINT INC
3.92%4.60M$65.8M
+62.83%(+1.77M)
2025-Q2: 0 shares2025-Q3: 0 shares2025-Q4: 0 shares2026-Q1: 2.83M shares2026-Q2: 4.60M shares
$14.61(+0.93%)
2026-06-30

About Commodore Capital LPโ€™s portfolio

Commodore Capital LP reports $1.68B in US-listed equity holdings across 33 positions in its most recent 13F filing. Its largest disclosed positions are RLAY (13.4%), ELVN (9.9%) and ALKS (9.4%). The top 20 holdings account for 91.87% of reported assets. Its disclosed equity book has returned +172.73% on a three-year cumulative basis. Figures reflect the Q2 2026 filing.

Portfolio concentration

Portfolio concentration
RLAY โ€” 13.4% ($224.52M)ELVN โ€” 9.9% ($166.21M)ALKS โ€” 9.4% ($157.19M)COGT โ€” 7.1% ($118.03M)AMLX โ€” 6.1% ($101.47M)DFTX โ€” 5.6% ($94.08M)SYRE โ€” 4.5% ($75.18M)ANRO โ€” 4.3% ($71.87M)TNGX โ€” 4.2% ($70.33M)EYPT โ€” 3.9% ($65.78M)Other โ€” 31.6% ($528.96M)
68%in top 10
  • RLAY13.4%
  • ELVN9.9%
  • ALKS9.4%
  • COGT7.1%
  • AMLX6.1%
  • DFTX5.6%
  • SYRE4.5%
  • ANRO4.3%
  • TNGX4.2%
  • EYPT3.9%
  • Other31.6%

Portfolio changes

What the fund actually did

Every reported change this quarter, grouped by direction. The signal is in the rotation, not any single trade.

New buys
4
TNGXTANGO THERAPEUTICS INC4.2%
EDITEDITAS MEDICINE INC1.7%
IFRXINFLARX NV1.0%
VTGNVISTAGEN THERAPEUTICS INC0.0%
Added to
6
EYPTEYEPOINT INC+62.8%
ASMBASSEMBLY BIOSCIENCES INC+41.5%
AVTXAVALO THERAPEUTICS INC+110.8%
COGTCOGENT BIOSCIENCES INC+5.6%
+2 more
Trimmed
9
SYRESPYRE THERAPEUTICS INC-55.7%
RLAYRELAY THERAPEUTICS INC-29.4%
NUVLNUVALENT INC-88.0%
ALKSALKERMES PLC-28.6%
+5 more

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Source filings

Holdings on this page are parsed from Commodore Capital LPโ€™s Form 13F filings with the U.S. Securities and Exchange Commission (CIK 1831942). View Commodore Capital LPโ€™s 13F filings on SEC

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