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Dafna Capital Management 13F Portfolio ยท Nathan Fischel

Portfolio Manager
Nathan Fischel
Performance
+34.68% (2026 Q2)
AUM (13F)
$524.36M
# of Holdings
88
Performance Rank
Allocation (Top 20)
72.95%
Latest filing
Q2 2026

Dafna Capital Management LLC Holdings Map

Top 50 Dafna Capital Management LLC Holdings

Top 10 holdings

StockCompany% Port.SharesValueActivityOwnershipAvg. CostDate
RVMD
REVOLUTION MEDICINES INC
20.09%562.6K$105.4M
-3.11%(-18.05K)
2025-Q2: 677.2K shares2025-Q3: 657.2K shares2025-Q4: 604.5K shares2026-Q1: 580.7K shares2026-Q2: 562.6K shares
$32.03(+570.11%)
2026-06-30
XBI
SPDR S&P BIOTECH ETF
5.93%196.5K$31.1M
-38.30%(-122.00K)
2025-Q2: 415.5K shares2025-Q3: 401.5K shares2025-Q4: 336.5K shares2026-Q1: 318.5K shares2026-Q2: 196.5K shares
$90.34(+74.90%)
2026-06-30
CMPS
COMPASS PATHWAYS PLC
5.43%2.01M$28.5M
-16.82%(-406.93K)
2025-Q2: 811.0K shares2025-Q3: 811.0K shares2025-Q4: 811.0K shares2026-Q1: 2.42M shares2026-Q2: 2.01M shares
$5.88(+128.60%)
2026-06-30
STXS
STEREOTAXIS INC
4.49%13.68M$23.5M
+0.00%(+0)
2025-Q2: 13.68M shares2025-Q3: 13.68M shares2025-Q4: 13.68M shares2026-Q1: 13.68M shares2026-Q2: 13.68M shares
$1.03(+33.86%)
2026-06-30
NKTR
NEKTAR THERAPEUTICS
4.24%318.4K$22.2M
+92.75%(+153.20K)
2025-Q2: 10.0K shares2025-Q3: 55.0K shares2025-Q4: 75.0K shares2026-Q1: 165.2K shares2026-Q2: 318.4K shares
$58.21(+26.87%)
2026-06-30
DNLI
DENALI THERAPEUTICS INC
3.62%739.0K$19.0M
+132.03%(+420.51K)
2025-Q2: 168.5K shares2025-Q3: 168.5K shares2025-Q4: 318.5K shares2026-Q1: 318.5K shares2026-Q2: 739.0K shares
$19.34(+26.16%)
2026-06-30
IDYA
IDEAYA BIOSCIENCES INC
3.53%497.2K$18.5M
+4.30%(+20.50K)
2025-Q2: 619.1K shares2025-Q3: 539.9K shares2025-Q4: 506.7K shares2026-Q1: 476.7K shares2026-Q2: 497.2K shares
$19.95(+81.97%)
2026-06-30
ATRC
ATRICURE INC
3.19%597.4K$16.7M
+0.00%(+0)
2025-Q2: 592.3K shares2025-Q3: 592.3K shares2025-Q4: 597.4K shares2026-Q1: 597.4K shares2026-Q2: 597.4K shares
$27.99(+59.96%)
2026-06-30
XENE
XENON PHARMACEUTICALS INC
2.89%250.8K$15.1M
+0.00%(+0)
2025-Q2: 287.9K shares2025-Q3: 287.9K shares2025-Q4: 287.9K shares2026-Q1: 250.8K shares2026-Q2: 250.8K shares
$14.00(+345.47%)
2026-06-30
CYTK
CYTOKINETICS INC
2.79%172.0K$14.7M
-20.92%(-45.50K)
2025-Q2: 398.1K shares2025-Q3: 394.9K shares2025-Q4: 371.0K shares2026-Q1: 217.5K shares2026-Q2: 172.0K shares
$33.77(+119.94%)
2026-06-30

About Dafna Capital Management LLCโ€™s portfolio

Dafna Capital Management LLC reports $524.36M in US-listed equity holdings across 88 positions in its most recent 13F filing. Its largest disclosed positions are RVMD (20.1%), XBI (5.9%) and CMPS (5.4%). The top 20 holdings account for 72.95% of reported assets. Its disclosed equity book has returned +122.22% on a three-year cumulative basis. Figures reflect the Q2 2026 filing.

Portfolio concentration

Portfolio concentration
RVMD โ€” 21.8% ($105.37M)XBI โ€” 6.4% ($31.10M)CMPS โ€” 5.9% ($28.47M)STXS โ€” 4.9% ($23.53M)NKTR โ€” 4.6% ($22.23M)DNLI โ€” 3.9% ($19.01M)IDYA โ€” 3.8% ($18.53M)ATRC โ€” 3.5% ($16.72M)XENE โ€” 3.1% ($15.14M)CYTK โ€” 3.0% ($14.65M)Other โ€” 38.9% ($187.63M)
61%in top 10
  • RVMD21.8%
  • XBI6.4%
  • CMPS5.9%
  • STXS4.9%
  • NKTR4.6%
  • DNLI3.9%
  • IDYA3.8%
  • ATRC3.5%
  • XENE3.1%
  • CYTK3.0%
  • Other38.9%

Portfolio changes

What the fund actually did

Every reported change this quarter, grouped by direction. The signal is in the rotation, not any single trade.

New buys
3
KYMRKYMERA THERAPEUTICS INC0.6%
ANLADLAI NORTYE LTD0.5%
NGENNERVGEN PHARMA CORP0.4%
Added to
13
DNLIDENALI THERAPEUTICS INC+132.0%
NKTRNEKTAR THERAPEUTICS+92.7%
PODDINSULET CORP+469.2%
EWTXEDGEWISE THERAPEUTICS INC+102.1%
+9 more
Trimmed
18
XBISPDR S&P BIOTECH ETF-38.3%
BHVNBIOHAVEN LTD-83.7%
CMPSCOMPASS PATHWAYS PLC-16.8%
BCAXBICARA THERAPEUTICS INC-32.4%
+14 more

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Source filings

Holdings on this page are parsed from Dafna Capital Management LLCโ€™s Form 13F filings with the U.S. Securities and Exchange Commission (CIK 1389933). View Dafna Capital Management LLCโ€™s 13F filings on SEC

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